Eye Injections / Ophthalmics – For Eye Health
Ophthalmics is the pharmaceutical field dedicated to the health of our eyes. It encompasses the development and provision of medications for the prevention and treatment of eye diseases such as glaucoma, age-related retinal changes, or dry eye syndrome. In addition to eye drops, certain conditions require injections, in which the active ingredient is administered directly into the eye under sterile conditions to act precisely and effectively.
Modern therapies aim to preserve vision, alleviate discomfort, and sustainably improve quality of life – in a safe, effective, and user-friendly way.
PSM focuses specifically on injectable ophthalmic medicines, supplied in vials or PFS (pre-filled syringe) formats. Techniques are employed to enable reliable filling of very small volumes, down to 100 microliters, under fully controlled processes.
Facilities and Processes for Injectable Ophthalmic Products
- Single-use compounding with batch sizes of up to 100 L
- Sterile filtration using single-use filters and product tubing, including PUPSIT
- Use of all common pre-sterilized packaging, such as PFS syringes and vials
- Filling in a sterile Class A cleanroom with state-of-the-art Groninger technology, focusing on the highest standards, minimal product loss, and maximum dosing precision:
- Equipment priming at the start of each batch
- 100 % weight inspection with top-up for underfills
- Filling volumes as low as 100 microliters
- Various pumping systems, stopper placement via vacuum or insertion tube, and optional gassing
- Fully automated and controlled movements with no human intervention in core processes
- Optical inspection, CCIT, and packaging
- Cold storage and GDP-compliant transport at 2–8 °C
With the Robocell filling system from Groninger and SKAN, we can fill batch sizes of up to 100 liters. We offer maximum flexibility in processing ready-to-use syringes up to 10 ml, vials up to 50 ml, and cartridges up to 3 ml in glass or polymer, while ensuring minimal product losses with 100 % check weight control.
With the Groninger Flexfill filling system, we can fill batch sizes of up to 600 liters. We offer maximum flexibility in processing ready-to-use syringes up to 50 ml, vials up to 100 ml, and cartridges up to 3 ml in glass or polymer. This line is equipped with peristalitc and rotary piston pumps and various gassing and vacuum options.
