mRNA Technologies: Innovation, Precision, and Flexibility
Messenger RNA provides instructions for making specific proteins. mRNA products are a new class of therapeutics that can be developed quickly and precisely. Synthetic mRNA allows targeted, temporary production of therapeutically relevant proteins in the body without altering the genome.
Thanks to their platform nature, mRNA technologies can be flexibly adapted to a wide range of indications, unlocking new potential for vaccines, oncology, and personalized therapies. They combine scientific excellence with scalable industrial implementation.
Our Facilities and Processes for Sterile mRNA Filling Include:
- Storage of APIs at −80 °C
- Controlled thawing process using HOF thawing units
- Single-use compounding with batch sizes of up to 100 L
- Sterile filtration with single-use filters and product tubing, including PUPSIT
- Use of all common pre-sterilized packaging, such as PFS syringes, vials, or cartridges
- Aseptic manufacturing is carried out using state-of-the-art Groninger filling systems, with a focus on the highest standards and minimal product loss:
- Equipment priming at the start of each batch
- 100 % weight inspection with top-up for underfills
- Various pumping systems, stopper placement via vacuum or insertion tube, and optional gassing
- Fully automated and controlled movements with no human intervention in core processes
- Optical inspection, CCIT, and packaging
- Cold storage and GDP-compliant transport at 2–8 °C
For specialized applications in rare diseases or personalized medicine with even smaller batch sizes, we also offer the full GMP-compliant process chain. The maximum batch size in this case is 20 L.
With the Robocell filling system from Groninger and SKAN, we can fill batch sizes of up to 100 liters. We offer maximum flexibility in processing ready-to-use syringes up to 10 ml, vials up to 50 ml, and cartridges up to 10 ml in glass or polymer, while ensuring minimal product losses with 100 % check weight control.
With the Groninger Flexfill filling system, we can fill batch sizes of up to 100 liters. We offer maximum flexibility in processing ready-to-use syringes up to 50 ml, vials up to 100 ml, and cartridges up to 10 ml in glass or polymer. This line is equipped with peristalitc and rotary piston pumps and various gassing and vacuum options.
