{"id":16302,"date":"2026-01-29T14:43:17","date_gmt":"2026-01-29T13:43:17","guid":{"rendered":"https:\/\/psm-saar.de\/?page_id=16302"},"modified":"2026-02-12T18:39:27","modified_gmt":"2026-02-12T17:39:27","slug":"monoclonal-antibodies","status":"publish","type":"page","link":"https:\/\/psm-saar.de\/en\/biopharmaceuticals\/monoclonal-antibodies\/","title":{"rendered":"Monoclonal Antibodies"},"content":{"rendered":"<div class=\"gb-container gb-container-a579df3d\"><div class=\"gb-inside-container\">\n<div class=\"gb-container gb-container-cb1d4eec\">\n\n<h1 class=\"gb-headline gb-headline-1a6fe487 gb-headline-text\">Monoclonal Antibodies (mAbs)<\/h1>\n\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-d755006d\">\n<div class=\"gb-grid-column gb-grid-column-fd0e5481\"><div class=\"gb-container gb-container-fd0e5481\"><div class=\"gb-inside-container\">\n\n<p>A monoclonal antibody is a laboratory-produced immune system protein that binds specifically to a single, well-defined target on a cell. It originates from a single cell line and is therefore completely uniform in structure and function. Monoclonal antibodies can block disease signals, modulate immune responses, or deliver therapeutic agents directly to specific cells. They are primarily used in cancer, autoimmune, and inflammatory therapies, as well as in diagnostics.<\/p>\n\n<\/div><\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-cd3d5425\"><div class=\"gb-container gb-container-cd3d5425\"><div class=\"gb-inside-container\">\n\n<p>At PSM, we have focused, among other things, on monoclonal antibodies (mAbs) and offer GMP-compliant, comprehensive process solutions. This includes all processes from freezing, controlled thawing, to formulation, filling, and visual inspection. For monoclonal antibodies for rare diseases, and therefore smaller batches, we use a dedicated Groninger filling line, which significantly reduces product loss during the process compared to conventional filling lines.<\/p>\n\n<\/div><\/div><\/div>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-text-color has-accent-2-color has-alpha-channel-opacity has-accent-2-background-color has-background is-style-default\"\/>\n\n\n\n<div>\n<h2 class=\"wp-block-heading\">PSM equipment and processes are implemented for handling mAbs:<\/h2>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Storage of APIs at \u221280\u202f\u00b0C<\/li>\n\n\n\n<li>Controlled thawing process using HOF thawing units<\/li>\n\n\n\n<li>Single-use compounding with batch sizes of up to 100\u202fL<\/li>\n\n\n\n<li>Sterile filtration with single-use filters and product tubing, including PUPSIT<\/li>\n\n\n\n<li>Use of all common pre-sterilized packaging, such as PFS syringes, vials, or cartridges<\/li>\n\n\n\n<li>Sterile filling using state-of-the-art Groninger technology, with a focus on the highest quality standards and minimal product loss:\n<ul class=\"wp-block-list\">\n<li>Equipment priming at the start of each batch<\/li>\n\n\n\n<li>100\u202f% weight inspection with top-up for underfills<\/li>\n\n\n\n<li>Various pumping systems, stopper placement via vacuum or insertion tube, and optional gassing<\/li>\n\n\n\n<li>Fully automated and controlled movements with no human intervention in core processes<\/li>\n\n\n\n<li>Minimal product loss throughout the entire processing chain<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Optical inspection, CCIT, and packaging<\/li>\n\n\n\n<li>Cold storage and GDP-compliant transport at 2\u20138\u202f\u00b0C<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-accent-2-color has-alpha-channel-opacity has-accent-2-background-color has-background is-style-default\"\/>\n\n<\/div>\n\n<div class=\"gb-container gb-container-c299afac\">\n\n<p>With the <strong>Robocell filling system<\/strong> from Groninger and SKAN, we can fill batch sizes of up to 100&nbsp;liters. We offer maximum flexibility in processing ready-to-use syringes up to 10&nbsp;ml, vials up to 50&nbsp;ml, and cartridges up to 10&nbsp;ml in glass or polymer, while ensuring minimal product losses with 100&nbsp;% check weight control.<\/p>\n\n\n<div class=\"gb-container gb-container-763e1020\">\n\n<figure class=\"wp-block-video\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2026\/01\/PSM-robocell-2026.mp4\"><\/video><\/figure>\n\n<\/div>\n\n\n<hr class=\"wp-block-separator has-text-color has-accent-2-color has-alpha-channel-opacity has-accent-2-background-color has-background\"\/>\n\n<\/div>\n\n<div class=\"gb-container gb-container-2d66c76e\">\n\n<p>With the Groninger <strong>Flexfill filling system<\/strong>, we can fill batch sizes of up to 600&nbsp;liters. We offer maximum flexibility in processing ready-to-use syringes up to 50&nbsp;ml, vials up to 100&nbsp;ml, and cartridges up to 10&nbsp;ml in glass or polymer. This line is equipped with peristalitc and rotary piston pumps and various gassing and vacuum options.<\/p>\n\n\n<div class=\"gb-container gb-container-e4bd32c0\">\n\n<figure class=\"wp-block-video\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2026\/01\/PSM-flexfill-2026.mp4\"><\/video><\/figure>\n\n<\/div>\n\n\n<hr class=\"wp-block-separator has-text-color has-accent-2-color has-alpha-channel-opacity has-accent-2-background-color has-background\"\/>\n\n\n<div class=\"gb-container gb-container-772bfa3b\"><div class=\"gb-inside-container\">\n<div class=\"gb-container gb-container-772bfa3b\"><div class=\"gb-inside-container\">\n\n<h3 class=\"gb-headline gb-headline-4eb99f69 gb-headline-text\">Our Services as an End-to-End Pharma CDMO<\/h3>\n\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-6a9f5337\">\n<div class=\"gb-grid-column gb-grid-column-f1a80c71\"><div class=\"gb-container gb-container-f1a80c71 kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-cdmo-deutschland\/api-manufacturing\/\" aria-label=\"More about our api manufacturing services\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-wirkstoff.png\" alt=\"\" class=\"wp-image-10115\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-5fb709cd\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-e28a1954 gb-headline-text\"><a title=\"\" href=\"https:\/\/psm-saar.de\/en\/pharma-cdmo-deutschland\/api-manufacturing\/\">API Manufacturing<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-c5a9fb3d\"><div class=\"gb-container gb-container-c5a9fb3d kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/formulation-development\/\" aria-label=\"Go to formulation and development\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-formulierungsentwicklung.png\" alt=\"\" class=\"wp-image-10121\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-04d8c970\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-ecc83657 gb-headline-text\"><a href=\"#\">Method and Process Development<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-d7793a7f\"><div class=\"gb-container gb-container-d7793a7f kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/analytik\/\" aria-label=\"Got to analytical services\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full is-resized kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-analytik.png\" alt=\"\" class=\"wp-image-10117\" style=\"width:200px\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-01eb533c\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-88da68ee gb-headline-text\"><a href=\"#\">Analytical Services<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-3c1bb04b\"><div class=\"gb-container gb-container-3c1bb04b kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/finished-medical-products\/\" aria-label=\"Go to aseptic filling services for clinical trials\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-klinische-muster.png\" alt=\"\" class=\"wp-image-10109\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-8e03e872\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-23351a9a gb-headline-text\"><a href=\"#\" title=\"\">Aseptic Fill &amp; Finish Services for Clinical Trials<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-db36bb92\"><div class=\"gb-container gb-container-db36bb92 kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/fill-finish-services-commercial\/\" aria-label=\"Go to aseptic filling services for commercial products\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2025\/11\/fill-and-finish-service-for-medicals.png\" alt=\"Pharmaceutical Fill and Finish Services\" class=\"wp-image-15984\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-35fd1dda\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-dc020a7a gb-headline-text\"><a href=\"#\">Aseptic Fill &amp; Finish Services for Commercial Products<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-d11449ec\"><div class=\"gb-container gb-container-d11449ec kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/packaging\/\" aria-label=\"Go to container closure integrity testing - CCIT\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full is-resized kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-optische.png\" alt=\"\" class=\"wp-image-10111\" style=\"height:110px\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-e68592e1\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-60b3a7b5 gb-headline-text\"><a href=\"#\">Visual Inspection and Container Closure Integrity Testing<\/a><br><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-7d2ad7eb\"><div class=\"gb-container gb-container-7d2ad7eb kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/packaging\/\" aria-label=\"Got to secondary packaging and labelling\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full is-resized kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-sekundaerverpackung.png\" alt=\"\" class=\"wp-image-10113\" style=\"width:200px;height:100px\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-189ea72d\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-8f90c8f7 gb-headline-text\"><a href=\"#\"> Secondary Packaging<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-982fe98c\"><div class=\"gb-container gb-container-982fe98c kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-cdmo\/gmp-storage\/\" aria-label=\"Go to gmp storage\" rel=\"nofollow\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><a href=\"https:\/\/psm-saar.de\/en\/pharma-cdmo\/gmp-storage\/\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-gmp-lager.png\" alt=\"\" class=\"wp-image-10107\"\/><\/a><\/figure>\n\n\n<div class=\"gb-container gb-container-6a95d4f3\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-22f65d01 gb-headline-text\"><a href=\"#\" title=\"\">GMP Storage<\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-c361547a\"><div class=\"gb-container gb-container-c361547a kat-container\"><a class=\"gb-container-link\" href=\"https:\/\/psm-saar.de\/en\/pharma-dienstleistungen\/gdp-transports\/\" aria-label=\"Go to gdp transport\"><\/a>\n\n<figure class=\"wp-block-image aligncenter size-full kat-image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"100\" src=\"https:\/\/psm-saar.de\/wp-content\/uploads\/2023\/06\/icon-gdp-transport.png\" alt=\"\" class=\"wp-image-10105\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-9aa7aa6d\"><div class=\"gb-inside-container\">\n\n<h4 class=\"gb-headline gb-headline-08890297 gb-headline-text\"><a href=\"#\">GDP Transport <\/a><\/h4>\n\n<\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Monoclonal Antibodies (mAbs) PSM equipment and processes are implemented for handling mAbs: With the Robocell filling system from Groninger and &#8230; <a title=\"Monoclonal Antibodies\" class=\"read-more\" href=\"https:\/\/psm-saar.de\/en\/biopharmaceuticals\/monoclonal-antibodies\/\" aria-label=\"Read more about Monoclonal Antibodies\">weiterlesen &#8230;<\/a><\/p>\n","protected":false},"author":2,"featured_media":16307,"parent":12529,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16302","page","type-page","status-publish","has-post-thumbnail"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/pages\/16302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/comments?post=16302"}],"version-history":[{"count":11,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/pages\/16302\/revisions"}],"predecessor-version":[{"id":16959,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/pages\/16302\/revisions\/16959"}],"up":[{"embeddable":true,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/pages\/12529"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/media\/16307"}],"wp:attachment":[{"href":"https:\/\/psm-saar.de\/en\/wp-json\/wp\/v2\/media?parent=16302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}